O9126
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O9126
Sigma
Oxotremorine sesquifumarate salt
≥98% (HPLC), solid
| Synonym: | 1-(4-[1-Pyrrolidinyl]-2-butynyl)-2-pyrrolidinone, 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone |
| CAS Number: | 17360-35-9 |
| Linear Formula: | C12H18N2O · 1.5C4H4O4 |
| Molecular Weight: | 380.39 |
| EC Number: | 241-388-3 |
| MDL number: | MFCD00013163 |
| PubChem Substance ID: | 24278614 |
Description
| Biochem/physiol Actions | Oxotremorine sesquifumarate salt is a muscarinic acetylcholine receptor agonist with preference for the M2 receptor. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| mp | 102-105 °C(lit.) |
| solubility | H2O: 10 mg/mL |
| Gene Information | human ... CHRM2(1129) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 28-36/37-45 |
| RIDADR | UN2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UY6000000 |
References
| reference | Gupta, N., Muscarinic receptor M1 and M2 subtypes in the human eye: QNB, pirenzipine, oxotremorine, and AFDX-116 in vitro autoradiography. Br. J. Ophthalmol. 78, 555, (1994) |
| Ringdahl, B., and Jenden, D.J., Pharmacological properties of oxotremorine and its analogs. Life Sci. 32, 2401, (1983) | |
| Puolivali, J., Oxotremorine suppresses thalamocortical oscillations via thalamic muscarinic acetylcholine receptors. Psychopharmacology 140, 285, (1998) | |
| Aldrich MSDS 1, 1417:A / Corp MSDS 1 (2), 2668:D / FT-IR 1 (2), 945:C / FT-IR 2 (3), 4042:A / FT-NMR 1 (3), 529:B / IR-Spectra (3), 1439:B / IR-Spectra (2), 1256:F / NMR-Reference 2 (2), 960:D / RegBook 1 (2), 2709:K / Sax 6, 2105 / Sigma FT-IR 1 (2), 816:C / Structure Index 1, 427:C:3 |
